Yes, it is compatible with Nikon Z-series cameras when used with the Nikon FTZ or FTZ II mount adapter, though autofocus speed may vary compared to native Z lenses.
The Sigma 100-300mm f/4 EX DG HSM features a professional build but lacks modern rubber gaskets for full weather sealing. It is advised to use a rain cover in wet conditions.
Internal zooming means the lens does not physically extend when changing focal lengths, which prevents dust from being sucked into the barrel and maintains a consistent center of gravity.